Fig. 1. MitoKv1.3 functions in cells. Inhibition of mitoKv1.3 can give different outputs depending on the drug concentration. When used at high micromolar range, plasma membrane permeant Kv1.3 inhibitors are able to trigger cancer cell death by inducing a mitochondrial dependent oxidative stress, as has been demonstrated by in vitro, ex-vivo and in vivo experiments. Conversely, inhibition of the mitoKv1.3 at sub-lethal nanomolar concentration would lead to modulation of cell proliferation or to the tuning of intracellular signalling pathways, e.g. RAS or Wnt signalling.